ESI FAQ:
Epidural Steroid Injections (ESI): Frequently Asked Questions
What is an epidural steroid injection?
An epidural steroid injection places anti-inflammatory medication around an irritated spinal nerve to reduce pain that radiates into an arm or leg from a herniated disc, spinal stenosis, or nerve irritation. It's a non-surgical, outpatient procedure done under X-ray guidance, typically taking 15-30 minutes with no sedation required.
What types of ESI are there?
- Interlaminar - medication delivered broadly around the back of the epidural space; used when pain isn't limited to one specific nerve.
- Transforaminal - medication delivered precisely around one or two nerve root(s); used when imaging points to a specific level(s).
- Selective Nerve Root Block (SNRB) - a diagnostic version of the transforaminal approach, used to confirm which nerve is causing your symptoms.
What medication is used?
Most injections use a corticosteroid. We use a nonparticulate steroid (dexamethasone), which is safer if inadvertently placed near a blood vessel. Regenerative alternatives (such as platelet-rich plasma) may also be used as a steroid-sparing option for select patients.
What are the benefits?
- Reduced pain and inflammation
- Improved ability to participate in physical therapy
- May help you avoid or delay surgery
- Can help confirm which nerve is causing your symptoms
What are the risks?
Common and temporary: soreness, brief increase in pain, temporary numbness, or a mild headache.
Rare but serious: infection, bleeding, allergic reaction, nerve injury, or (very rarely) serious neurologic complications. These risks are minimized through X-ray guidance, contrast confirmation, and careful medication selection.
What are my alternatives to this procedure?
Physical therapy, oral medication, activity modification, observation, surgical referral, or declining treatment.
When should I call the office immediately?
Call right away if you experience fever, a severe or worsening headache, new weakness or numbness, or loss of bladder/bowel control.
Where can I learn more?
Visit our Services page for more on what to expect and how we tailor treatment to you: https://www.osso.health/services
Safety guidance adapted from the International Pain and Spine Intervention Society (IPSIS), 2025.

